2-(4-Fluorophenyl)-thiophene, identified by CAS 58861-48-6, is an aromatic thiophene derivative containing a fluorinated phenyl group. Based on its molecular structure, its molecular formula is C10H7FS and its calculated molecular weight is 178.23 g/mol. I regard this compound primarily as a research and synthesis intermediate for projects involving specialty organic molecules, electronic materials, and pharmaceutical or agrochemical discovery. Because physical appearance, purity, residual solvents, and analytical results can vary by manufacturing route and batch, I recommend confirming the current specification through a certificate of analysis before purchase.
The molecule consists of a thiophene ring connected at the 2-position to a para-fluorophenyl group. The thiophene portion contributes sulfur-containing aromaticity, while the fluorophenyl portion introduces a fluorine substituent and a second aromatic ring. This combination gives the compound a compact, conjugated structure that may be useful when researchers need to modify the electronic or steric characteristics of a larger target molecule.
| Property | Information |
|---|---|
| Common name | 2-(4-Fluorophenyl)-thiophene |
| CAS number | 58861-48-6 |
| Molecular formula | C10H7FS |
| Calculated molecular weight | 178.23 g/mol |
| Structural class | Fluorinated aryl thiophene |
The molecular weight shown above is calculated from the stated molecular formula and should not be confused with a batch-specific analytical result. For the same formula, the theoretical elemental composition is approximately 67.36% carbon, 3.96% hydrogen, 10.65% fluorine, and 17.99% sulfur by mass. These calculated values can help with identity review, but they do not replace techniques such as nuclear magnetic resonance spectroscopy, mass spectrometry, chromatography, or other agreed quality tests.
2-(4-Fluorophenyl)-thiophene contains two aromatic systems, so its chemical behavior is expected to be influenced by conjugation and aromatic ring interactions. The fluorine atom can alter electronic distribution without adding a large substituent, which is one reason fluorinated building blocks are frequently considered in medicinal chemistry and advanced materials research. The sulfur atom in thiophene also provides a distinctive heteroaromatic function for further synthetic planning.
I do not recommend assuming a melting point, boiling point, density, solubility profile, or physical state without a validated product specification. Such values may depend on isomeric purity, crystallinity, residual solvent, measurement method, and storage history. For a procurement decision, I suggest requesting the latest specification and batch COA rather than relying on generalized catalog data.
The most defensible description of this material is a specialty organic building block rather than a finished active ingredient. Researchers may evaluate it as an intermediate in the preparation of more complex fluorinated heteroaromatic compounds. Its suitability for a specific reaction must be confirmed experimentally because reaction performance depends on the selected catalyst, solvent, temperature, stoichiometry, and downstream purification process.
Fluorinated aromatic and heteroaromatic fragments are commonly explored during lead-generation and structure-activity studies. In this context, 2-(4-Fluorophenyl)-thiophene may serve as a fragment or intermediate incorporated into a larger research compound. I would not describe CAS 58861-48-6 itself as a pharmaceutical ingredient, approved drug substance, or therapeutic product unless a buyer has separate regulatory evidence for that use.
The conjugated thiophene-aryl framework may also be considered in research on functional organic molecules, including intermediates for optical, electronic, or semiconducting material studies. Performance cannot be inferred from the name alone, and material properties depend strongly on the complete molecular architecture. Researchers should therefore evaluate the final compound, not only the contribution of this intermediate, through their own application-specific testing.
Contract research organizations and chemical manufacturers may use this compound as a starting material for route development, analog preparation, or library synthesis. It can be especially relevant when a project requires a defined fluorinated aryl-thiophene motif. Before placing an order, I recommend confirming whether the supplier supports only standard supply or can also discuss custom synthesis, scale-up, and packaging requirements.
Link to Maison Chemical
Commercial availability may differ by purity grade, packaging format, and intended use. A discovery-scale buyer may prioritize high analytical purity and a small evaluation quantity, while a process-development buyer may require consistent impurity control, larger packaging, and documented batch-to-batch comparability. These are different procurement requirements even when the chemical name and CAS number are identical.
| Buyer requirement | Recommended specification focus |
|---|---|
| Early research | Identity confirmation, practical purity, small-pack availability, and technical response time |
| Route development | Impurity profile, reproducibility, reaction suitability, and scalable packaging |
| Commercial evaluation | Batch consistency, supply continuity, quality agreement, and logistics planning |
When a customer requests a purity target, I treat that target as a purchasing specification rather than an automatic product claim. The appropriate limit should be agreed according to the intended synthesis and analytical method. If the material is intended for a regulated development program, the buyer should also clarify whether additional documentation, change notification, traceability, or supplier qualification is required.
I recommend handling this compound as a laboratory chemical and following the supplier’s current safety data sheet. Personnel should use suitable laboratory controls, including appropriate protective equipment, ventilation, labeled containers, and procedures for accidental release. The exact hazard classification should be taken from the applicable SDS and regional regulations rather than inferred only from the presence of fluorine or sulfur.
Storage conditions should be confirmed before shipment and maintained throughout the supply chain. In general, buyers should protect the material from incompatible conditions, unnecessary heat, moisture, and contamination, while keeping the original label and batch information available. Any transfer into secondary containers should preserve the product identity, hazard information, and traceability.
For this type of intermediate, I recommend evaluating the supplier on technical evidence and supply discipline rather than on a low quoted price alone. The supplier should be able to match the product to CAS 58861-48-6, explain the available grade, and provide documentation appropriate to the buyer’s use. A clear response to technical questions is also important because it helps identify specification gaps before an order is placed.
At Maison Chemical, I approach 2-(4-Fluorophenyl)-thiophene as a B2B specialty chemical requirement that needs both product accuracy and practical supply support. I can help buyers review the requested identity, clarify specification needs, discuss packaging and order quantities, and coordinate documentation for evaluation. Availability, purity, price, and lead time should be confirmed for each inquiry because they depend on the requested grade, quantity, and production schedule.
In direct answer to the question, 2-(4-Fluorophenyl)-thiophene CAS 58861-48-6 is a fluorinated thiophene-based aromatic intermediate used for research and further organic synthesis. Its defined molecular identity makes it a useful starting point for pharmaceutical discovery, custom synthesis, and selected advanced-materials investigations, but application performance must be confirmed in the buyer’s own chemistry. The most reliable purchasing decision comes from matching the required grade and documentation to the intended use.
For the next step, I recommend sending Maison Chemical the required quantity, target purity, application type, packaging preference, destination country, and requested delivery schedule. I can then help clarify the available specification, documentation, commercial terms, and supply route for your project. This approach allows buyers to assess CAS 58861-48-6 on verified information before committing to laboratory or process-scale work.
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