CAS 25655-41-8 Povidone-Iodine: Specifications, Uses, and Buyer’s Sourcing Guide
CAS 25655-41-8 identifies povidone-iodine, also called PVP-I: a complex of povidone and iodine used in products such as topical antiseptic solutions and surgical preparations. For B2B buyers, the key specification is usually available iodine, not simply the total amount of PVP-I in a formulation. A commonly referenced assay range for povidone-iodine substance is 9.0–12.0% available iodine by weight, but buyers should confirm the applicable grade, pharmacopoeia, and current certificate of analysis (COA) before ordering. At NKY Group, we recommend matching the requested material and documentation to its intended use before comparing quotations.
Key Takeaways
- CAS 25655-41-8 refers to the povidone-iodine complex, not elemental iodine alone or a finished antiseptic product.
- Available iodine, grade, test methods, and intended application are central to a useful specification comparison.
- A 10% w/w PVP-I solution is a common product strength; it is not the same as 10% available iodine.
- Before purchasing, request a current COA, confirm packaging and shipping requirements, and clarify the intended regulatory market.
Who This Guide Is For
This guide is for procurement teams, formulators, distributors, and manufacturers evaluating povidone-iodine as a raw material or sourcing ingredient. It is intended to support supplier screening and specification discussions, rather than replace a product monograph, regulatory review, or qualified technical assessment. Requirements can differ between pharmaceutical, healthcare, veterinary, and other applications. Buyers should define the destination market and end use before requesting a quotation.
What Is Povidone-Iodine?
Povidone-iodine is a complex in which iodine is associated with povidone, a water-soluble polymer. The complex serves as a carrier for iodine, which is released from the system under suitable conditions. This distinguishes PVP-I from a simple iodine solution and means that material identity, available iodine, and formulation characteristics all matter when assessing a product.
Raw Material Versus Finished Formulation
CAS 25655-41-8 identifies the PVP-I substance, while a finished product may also contain water, surfactants, or other formulation ingredients. For example, a 10% w/w PVP-I solution contains 10% povidone-iodine complex by weight; it should not be interpreted as containing 10% available iodine. A commonly encountered 10% PVP-I topical formulation is often described as providing approximately 1% available iodine, but the exact value and labeling depend on the product specification and market.
Specifications and Material Options
A supplier quotation should state precisely what is being offered: the substance or a formulated product, the grade, and the relevant specification. Pharmacopeial or customer-specific requirements should be named rather than assumed. The commonly referenced 9.0–12.0% w/w available-iodine range is a useful point for specification discussions, but it does not by itself establish that a particular batch meets a buyer’s full requirements.
What to Review in a Specification
| Specification area | What buyers should confirm |
|---|---|
| Identity | CAS number, material name, grade, and whether the offer is raw PVP-I or a finished preparation. |
| Assay | Available-iodine range, test method, and the basis for reporting, such as percentage by weight. |
| Quality attributes | Applicable limits and methods for appearance, moisture, solubility, and other requested tests. |
| Documentation | Batch-specific COA, specification sheet, safety data sheet, and any other documents required for the application. |
| Packaging and handling | Pack size, closure and liner details, storage instructions, shelf-life information, and shipping conditions. |
Do not assume that every supplier uses identical test methods or acceptance criteria. Compare the stated method and units as well as the numerical result, and ask whether the documents apply to the offered batch or only describe a general product. If you require compliance with a specific pharmacopoeia or internal standard, name it in the inquiry and request confirmation in writing.
Matching Povidone-Iodine to an Application
PVP-I is used in a range of topical and healthcare-related products, including antiseptic solutions, surgical preparations, and certain oral or veterinary formulations. The material grade and formulation requirements depend on the product being manufactured, its route of use, and the rules applicable in the target market. A raw-material purchase is not, by itself, evidence that a finished product is approved or suitable for a particular medical use.
Questions to Clarify Before Ordering
- Will the material be used as a raw ingredient, or are you sourcing a ready-to-use formulation?
- What available-iodine assay and test method does your product specification require?
- Which market, product category, and regulatory framework apply?
- Are there customer requirements for packaging, batch traceability, or document review?
A Practical Supplier Selection Framework
A reliable comparison starts with a complete product brief. Provide the CAS number, required grade, target assay, applicable specification, annual or trial volume, destination, and requested delivery window. This gives suppliers enough context to respond with comparable offers and identify any gap between the requested and available material.
NKY Group contains other products and information you need, so please check it out.
Supplier Evaluation Checklist
- Confirm product identity. Check that the quote and documents refer to CAS 25655-41-8 and distinguish the raw material from any formulated product.
- Review batch evidence. Request a current COA and check the assay, units, methods, batch identifier, and test results against your requirements.
- Assess documentation fit. Confirm which quality documents are available and whether they meet your internal review and destination-market needs.
- Discuss logistics. Verify pack size, packaging suitability, storage guidance, shipping arrangements, and any import documentation responsibilities.
- Resolve deviations before purchase. Record any differences in grade, method, specification, or packaging and obtain agreement before placing an order.
Pricing, MOQ, and Lead Time
Price is influenced by factors such as grade, specification, order quantity, packaging, documentation needs, and shipping destination. Minimum order quantity (MOQ) and lead time can also vary with stock status, production planning, and the requested configuration. Because these details are order-specific, buyers should obtain a current written quotation rather than rely on a general market estimate.
For a more useful quote, specify whether you need a sample, a trial quantity, or commercial supply, and state your target delivery date. Ask the supplier to confirm quotation validity, available pack sizes, shipment terms, and whether the quoted material matches your full specification. If your project has a fixed launch schedule, include time for document review and incoming-material qualification in your procurement plan.
Common Sourcing Mistakes to Avoid
One frequent mistake is treating 10% PVP-I and 10% available iodine as interchangeable descriptions. They refer to different concentration bases, so buyers should request clear labeling and assay details. Another is comparing prices before confirming that suppliers are quoting the same grade, specification, and packaging configuration.
Buyers should also avoid assuming that a general product sheet proves a specific batch meets a requirement. Request batch-level evidence and clarify any missing test, method, or document before shipment. Finally, do not rely on a supplier’s generic regulatory language as a substitute for your own assessment of the finished product and its intended market.
How NKY Group Can Support Your Inquiry
At NKY Group, we support B2B sourcing inquiries by reviewing the requested CAS number, grade, assay, application, quantity, and destination before preparing a proposal. Sharing your specification and document checklist at the outset helps us assess the fit of an available offer and identify questions that should be resolved before ordering. Product availability, MOQ, lead time, and documentation are confirmed for each inquiry.
Conclusion: How to Source CAS 25655-41-8
CAS 25655-41-8 identifies povidone-iodine, but a CAS match alone is not enough to select a suitable supply. Define the intended use and market, specify the required available-iodine assay and grade, and evaluate batch documentation, packaging, and logistics together. Treat the commonly referenced 9.0–12.0% w/w available-iodine range as a specification discussion point, not a substitute for the requirements governing your purchase.
To move forward, send NKY Group your target specification, required quantity, destination, and document needs. We can review the inquiry and provide current availability and quotation details for your evaluation. Confirm that the proposed material and documentation meet your internal qualification process before placing an order.